Dose-independent pharmacokinetics of a new reversible proton pump inhibitor, KR-60436, after intravenous and oral administration to rats: gastrointestinal first-pass effect.

@article{Yu2003DoseindependentPO,
  title={Dose-independent pharmacokinetics of a new reversible proton pump inhibitor, KR-60436, after intravenous and oral administration to rats: gastrointestinal first-pass effect.},
  author={Su Yeon Yu and Soo Hyeon Bae and Eun Jung Kim and Yoon Gyoon Kim and Sun-Ok Kim and Dong Ha Lee and Hong Lim Lim and Myung Gull Lee},
  journal={Journal of pharmaceutical sciences},
  year={2003},
  volume={92 8},
  pages={1592-603}
}
Dose-independent pharmacokinetic parameters of KR-60436, a new proton pump inhibitor, were evaluated after intravenous (i.v.; 5, 10, and 20 mg/kg) and oral (20, 50, and 100 mg/kg) administration to rats. The hepatic, gastric, and intestinal first-pass effects were also measured after iv, intraportal (i.p.), intragastric (i.g.), and intraduodenal (id) administrations to rats of a dose of 20 mg/kg. The areas under the plasma concentration-time curve from time to zero to time infinity (AUCs) were… CONTINUE READING