Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.

@article{Kkesi2004DoseindependentAI,
  title={Dose-independent antinociceptive interaction of endogenous ligands at the spinal level.},
  author={Gabriella K{\'e}kesi and Gabriella Jo{\'o} and Emese Csullog and Mihaly Peter-Szabo and Gyorgy Benedek and Gy{\"o}ngyi Horv{\'a}th},
  journal={Brain research},
  year={2004},
  volume={1029 1},
  pages={93-102}
}
Adenosine, agmatine and kynurenic acid are endogenous ligands acting on different (e.g. adenosine, NMDA, alpha(2)-adrenergic and imidazoline) receptors with a potential role in nociception at the spinal level. Their antinociceptive effects have already been investigated as monotherapy, but only a few studies have reported on their effects on the potency of other drugs. The purpose of the present study was carried out to analyse their interactions during continuous intrathecal co-administration… CONTINUE READING

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