Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia

@article{Arakawa2007DosefindingSO,
  title={Dose-finding study of paliperidone ER based on striatal and extrastriatal dopamine D2 receptor occupancy in patients with schizophrenia},
  author={Ryosuke Arakawa and Hiroshi Ito and Akihiro Takano and Hidehiko Takahashi and Takuya Morimoto and Takeshi Sassa and Katsuya Ohta and Motoichiro Kato and Yoshiro Okubo and Tetsuya Suhara},
  journal={Psychopharmacology},
  year={2007},
  volume={197},
  pages={229-235}
}
Paliperidone ER is a novel antipsychotic drug in an extended-release (ER) formulation. As with all antipsychotics, careful dose setting is necessary to avoid side effects. In this study, we measured striatal and extrastriatal dopamine D2 receptor occupancy during paliperidone ER treatment in patients with schizophrenia using positron emission tomography (PET) to compare regional occupancy and to estimate the optimal dose. Thirteen male patients with schizophrenia participated in this 6-week… CONTINUE READING