Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach.

@article{Ivanova2009DoseFF,
  title={Dose finding for continuous and ordinal outcomes with a monotone objective function: a unified approach.},
  author={Anastasia Ivanova and Se Hee Kim},
  journal={Biometrics},
  year={2009},
  volume={65 1},
  pages={307-15}
}
In many phase I trials, the design goal is to find the dose associated with a certain target toxicity rate. In some trials, the goal can be to find the dose with a certain weighted sum of rates of various toxicity grades. For others, the goal is to find the dose with a certain mean value of a continuous response. In this article, we describe a dose-finding design that can be used in any of the dose-finding trials described above, trials where the target dose is defined as the dose at which a… CONTINUE READING

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