Dose-finding designs for HIV studies.

  title={Dose-finding designs for HIV studies.},
  author={J O'quigley and Michael L. Hughes and Terry Fenton},
  volume={57 4},
We present a class of simple designs that can be used in early dose-finding studies in HIV. Such designs, in contrast with Phase I designs in cancer, have a lot of the Phase II flavor about them. Information on efficacy is obtained during the trial and is as important as that relating to toxicity. The designs proposed here sequentially incorporate the information obtained on viral reduction. Initial doses are given from some fixed range of dose regimens. The doses are ordered in terms of their… CONTINUE READING

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