Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer.

@article{Zelefsky1998DoseEW,
  title={Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer.},
  author={Michael J Zelefsky and Steven A. Leibel and Paul B Gaudin and Gerald J. Kutcher and Neil E. Fleshner and E S Venkatramen and Victor E. Reuter and William R. Fair and C. Clifton Ling and Zvi Y. Fuks},
  journal={International journal of radiation oncology, biology, physics},
  year={1998},
  volume={41 3},
  pages={491-500}
}
PURPOSE Three-dimensional conformal radiation therapy (3D-CRT) is a technique designed to deliver prescribed radiation doses to localized tumors with high precision, while effectively excluding the surrounding normal tissues. It facilitates tumor dose escalation which should overcome the relative resistance of tumor clonogens to conventional radiation dose levels. The present study was undertaken to test this hypothesis in patients with clinically localized prostate cancer. METHODS AND… CONTINUE READING
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