Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma

@inproceedings{Boy2017DoseES,
  title={Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma},
  author={Pierre Boy{\'e} and François Serres and Laurent Marescaux and Juliette Hordeaux and Emmanuel Bouchaert and Bruno Squ{\'a}rcio Fernandes Gomes and Dominique Tierny},
  booktitle={PloS one},
  year={2017}
}
Comparative oncology has shown that naturally occurring canine cancers are of valuable and translatable interest for the understanding of human cancer biology and the characterization of new therapies. This work was part of a comparative oncology project assessing a new, clinical-stage topoisomerase II inhibitor and comparing it with etoposide in dogs with spontaneous lymphoma with the objective to translate findings from dogs to humans. Etoposide is a topoisomerase II inhibitor widely used in… CONTINUE READING