Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial.

@article{Hayman2001DoseEI,
  title={Dose escalation in non-small-cell lung cancer using three-dimensional conformal radiation therapy: update of a phase I trial.},
  author={James Alan Hayman and Mary K. Martel and Randall K. Ten Haken and Daniel P Normolle and Robert F. Todd and J F Littles and Molly A Sullivan and Peter W. Possert and Andrew T. Turrisi and Allen S. Lichter},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2001},
  volume={19 1},
  pages={127-36}
}
PURPOSE High-dose radiation may improve outcomes in non-small-cell lung cancer (NSCLC). By using three-dimensional conformal radiation therapy and limiting the target volume, we hypothesized that the dose could be safely escalated. MATERIALS AND METHODS A standard phase I design was used. Five bins were created based on the volume of normal lung irradiated, and dose levels within bins were chosen based on the estimated risk of radiation pneumonitis. Starting doses ranged from 63 to 84 Gy… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 65 extracted citations

Individualized higher dose of 70-75 Gy using five-fraction robotic stereotactic radiotherapy for non-small-cell lung cancer: a feasibility study.

Computer aided surgery : official journal of the International Society for Computer Aided Surgery • 2011
View 3 Excerpts
Highly Influenced

Feasibility of high-dose three-dimensional radiation therapy in the treatment of localised non-small-cell lung cancer.

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique • 2009
View 3 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…