Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs.

@article{Ameijden1999DoseeffectRB,
  title={Dose-effect relationship between overdose mortality and prescribed methadone dosage in low-threshold maintenance programs.},
  author={Erik J. C. van Ameijden and Miranda W. Langendam and Roel A. Coutinho},
  journal={Addictive behaviors},
  year={1999},
  volume={24 4},
  pages={559-63}
}
The present study evaluates the effectiveness of low-threshold methadone maintenance in reducing overdose mortality. In a prospective cohort study conducted in Amsterdam, 498 Dutch injecting drug users (IDU) provided 1,969 person years of follow-up (1989-1995). Forty-four IDU died in this period, 15 due to illicit drug overdose. Compared to IDU not in maintenance, the adjusted relative risk for overdose mortality among those receiving 5-50 mg, 55-70 mg, and 75+ mg were 0.35, 0.13, and 0.11… CONTINUE READING