Dose-effect and dose-response relationships for lead in children.

  title={Dose-effect and dose-response relationships for lead in children.},
  author={Julian J. Chisolm and Maureen B. Barrett and E. David Mellits},
  journal={The Journal of pediatrics},
  volume={87 6 Pt 2},
Lead absorption and prevention of the serious effects of lead re-examined from the viewpoints of the critical organ and clinical effect concepts and the associated dose-effect and dose-response relationships. If the critical organ is the first affected and the critical effect is the first measurable adverse effect, intervention on this basis should prevent the occurrence of later, more serious effects. In the range of lead absorption of greatest current pediatric concern (blood lead in the… CONTINUE READING
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