Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.

@article{Steger1997DosedependentRO,
  title={Dose-dependent regulation of the early promoter of human papillomavirus type 18 by the viral E2 protein.},
  author={Gerhard Steger and S Corbach},
  journal={Journal of virology},
  year={1997},
  volume={71 1},
  pages={50-8}
}
The activity of the E6/E7 promoter of genital human papillomaviruses (HPVs) is positively and negatively modulated by a complex interplay between a variety of cellular transcription factors and the virally encoded E2 protein. The long control region of genital HPVs contains four E2 binding sites in conserved positions, two of which are very close to the TATA box. Binding of E2 to these two sites has been shown to repress the promoter. To carefully analyze the effect of E2 on the activity of the… CONTINUE READING