Dose-dependent pharmacokinetics of ibuprofen in the rat.

  title={Dose-dependent pharmacokinetics of ibuprofen in the rat.},
  author={Anita L Shah and Donald Jung},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  volume={15 2},
The linearity of the pharmacokinetics of ibuprofen was examined in male Sprague-Dawley rats given iv bolus doses of 10, 20, and 50 mg/kg ibuprofen. Plasma and urine concentrations of ibuprofen and its two major metabolites, OH-ibuprofen and COOH-ibuprofen, were determined by HPLC and the binding of ibuprofen to plasma proteins was measured by an ultrafiltration technique. The systemic plasma clearance (CLtot) of ibuprofen was dose-dependent and decreased from 0.29 to 0.14 liter/hr/kg primarily… CONTINUE READING

From This Paper

Topics from this paper.


Publications citing this paper.
Showing 1-10 of 10 extracted citations

Similar Papers

Loading similar papers…