Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans

  title={Dose-dependent pharmacokinetics of benzoic acid following oral administration of sodium benzoate to humans},
  author={Kiyoshi Kubota and Takashi Ishizaki},
  journal={European Journal of Clinical Pharmacology},
SummaryPlasma concentration-time data for benzoic and hippuric acids and urinary excretion-time data for hippuric acid were analyzed simultaneously after oral doses of 40, 80 or 160 mg/kg sodium benzoate administered at least one week apart to 6 healthy subjects.The mean AUCs of benzoic acid after the doses of 80 and 160 mg/kg of sodium benzoate were 3.7- and 12.0-times greater, respectively, than after 40 mg/kg. However, the mean AUC of hippuric acid was roughly proportional to the benzoate… 

Effect of single oral dose of sodium benzoate on ureagenesis in healthy men and two patients with late onset citrullinaemia

Examination of aspects of ureagenesis after the single oral dosing of sodium benzoate in six healthy subjects who participated in the study previously reported and in two patients with citrullinaemia found no apparent inhibitory effects on the UNA.

The Effect of Oral Intake of Sodium Benzoate on the Activity of Liver Marker Enzymes and Electrolyte Level of the Wistar Albino Rats

In vivo effect of oral administration of sodium benzoate on serum liver marker enzyme activity and electrolyte levels of wistar albino rats were investigated to suggest possible changes in blood chemistry due to the preservative.

Influence of coffee intake on urinary hippuric acid concentration.

The findings suggest that toluene exposure in coffee-consuming workers may be overestimated, and components of coffee, such as chlorogenic, caffeic, and quinic acids, are metabolized to HA.

Human variability for metabolic pathways with limited data (CYP2A6, CYP2C9, CYP2E1, ADH, esterases, glycine and sulphate conjugation).

  • J. DorneK. WaltonA. Renwick
  • Medicine, Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2004

Simultaneous LC-MS/MS determination of phenylbutyrate, phenylacetate benzoate and their corresponding metabolites phenylacetylglutamine and hippurate in blood and urine

This newly developed LC-MS/MS represents a robust, sensitive, and rapid method that allows simultaneous determination of the five compounds in plasma and urine from children with inborn errors of urea synthesis.



Drug biotransformation interactions in man. II. A pharmacokinetic study of the simultaneous conjugation of benzoic and salicylic acids with glycine.

Benzoic acid has a pronounced inhibitory effect on the formation of salicyluric acid from salicylic acid, and the results indicate that in man the availability of glycine is rate-limiting in theformation of hippuric Acid, but not inThe formation of SalicylURic acid.

Clinical Pharmacokinetics of the Salicylates

Pharmacokinetic parameters in patients with rheumatoid arthritis, osteoarthritis, chronic renal failure or liver disease are essentially the same, and no significant differences exist between the pharmacokinetics of the salicylates in the elderly or in children when compared with young adults.

Properties of the Michaelis-Menten equation and its integrated form which are useful in pharmacokinetics

  • J. Wagner
  • Chemistry
    Journal of Pharmacokinetics and Biopharmaceutics
  • 2005
Some old equations are reviewed and some new equations have been derived which indicate certain properties of the Michaelis-Menten equation and its integrated forms which indicate the hybrid nature of ko.

The potentiation of ammonia toxicity by sodium benzoate is prevented by L-carnitine.

Salicylate accumulation kinetics in man.

It is thus important to make upward adjustments of dosage cautiously, allowing sufficient time for body levels to reach the new steady state before the dosage is increased still further, according to the time required to attain the plateau.

Nonlinear elimination of benzoate in patients with congenital hyperammonemia.

The effect of sodium benzoate on ammonia toxicity in rats.

Importance of the use of the appropriate pharmacokinetic model to analyzein vivo enzyme constants

Simulated data, which obey the two-compartment open model with Michaelis-Menten elimination, and which illustrate some of the interesting properties of such models are presented.

Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion.

Activation of alternative pathways of waste nitrogen excretion can prolong survival and improve clinical outcome in children with inborn errors of urea synthesis.