Dose dependent pharmacokinetics of N-acetylcysteine after oral dosing to man.

@article{Borgstrm1990DoseDP,
  title={Dose dependent pharmacokinetics of N-acetylcysteine after oral dosing to man.},
  author={Lars Borgstr{\"o}m and Bertil K{\aa}gedal},
  journal={Biopharmaceutics & drug disposition},
  year={1990},
  volume={11 2},
  pages={131-6}
}
The pharmacokinetics after oral administration of 200, 600 or 1200 mg of N-acetylcysteine (NAC) were studied in 10 healthy subjects. Normalized maximal plasma concentration was significantly higher after a 600 mg dose than after a 200 mg dose. Bioavailability of NAC significantly increased with increasing dose. Time for maximal plasma concentration also increased with increasing dose. The observations can be explained by a capacity-limited presystemic elimination of NAC. In an extension of the… CONTINUE READING