Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma.

@article{Kharitonov2002DosedependentOA,
  title={Dose-dependent onset and cessation of action of inhaled budesonide on exhaled nitric oxide and symptoms in mild asthma.},
  author={Sergei A. Kharitonov and Louise E Donnelly and Paolo Montuschi and Maurizio Corradi and John H. Lienhard V Collins and Peter J Barnes},
  journal={Thorax},
  year={2002},
  volume={57 10},
  pages={889-96}
}
BACKGROUND Dose dependent anti-inflammatory effects of inhaled corticosteroids in asthma are difficult to demonstrate in clinical practice. The anti-inflammatory effect of low dose inhaled budesonide on non-invasive exhaled markers of inflammation and oxidative stress were assessed in patients with mild asthma. METHODS 28 patients entered a double blind, placebo controlled, parallel group study and were randomly given either 100 or 400 micro g budesonide or placebo once daily, inhaled from a… CONTINUE READING

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