Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine

  title={Dose-dependent inhibition of CYP1A2, CYP2C19 and CYP2D6 by citalopram, fluoxetine, fluvoxamine and paroxetine},
  author={U. Jeppesen and L. F. Gram and K. Vistisen and S. Loft and H. Poulsen and K. Br{\o}sen},
  journal={European Journal of Clinical Pharmacology},
  • U. Jeppesen, L. F. Gram, +3 authors K. Brøsen
  • Published 1996
  • Medicine
  • European Journal of Clinical Pharmacology
  • Objectives: The purpose of this pharmacokinetic study was to investigate the dose-dependent inhibition of model substrates for CYP2D6, CYP2C19 and CYP1A2 by four marketed selective serotonin reuptake inhibitors (SSRIs): citalopram, fluoxetine, fluvoxamine and paroxetine. [...] Key Method The volunteers received in randomised order, at weekly intervals, increasing single oral doses of one of the four SSRIs, followed 3 h later by sparteine (CYP2D6), mephenytoin (CYP2C19) and caffeine (CYP1A2) tests. Fluoxetine…Expand Abstract
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