Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.

@article{Mazzone2010DosedependentIO,
  title={Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.},
  author={Marco Mazzone and Laura M. Selfors and John G. Albeck and Michael G Overholtzer and Sanja {\vS}ale and Danielle L Carroll and Darshan Pandya and Yiling Lu and Gordon B. Mills and Jon C Aster and S. Artavanis-Tsakonas and Joan S. Brugge},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 11},
  pages={5012-7}
}
Aberrant activation of Notch receptors has been implicated in breast cancer; however, the mechanisms contributing to Notch-dependent transformation remain elusive because Notch displays dichotomous functional activities, promoting both proliferation and growth arrest. We investigated the cellular basis for the heterogeneous responses to Notch pathway activation in 3D cultures of MCF-10A mammary epithelial cells. Expression of a constitutively active Notch-1 intracellular domain (NICD) was found… CONTINUE READING
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