Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL.

  title={Dose-dependent increase of saquinavir bioavailability by the pharmaceutic aid cremophor EL.},
  author={M. Martin-Facklam and J. Burhenne and R. Ding and R. Fricker and G. Mikus and I. Walter-Sack and W. Haefeli},
  journal={British journal of clinical pharmacology},
  volume={53 6},
  • M. Martin-Facklam, J. Burhenne, +4 authors W. Haefeli
  • Published 2002
  • Medicine
  • British journal of clinical pharmacology
  • AIMS Bioavailability of orally administered drugs depends on several factors including active excretion, e.g. by P-glycoprotein (PGP), and presystemic metabolism, e.g. by cytochrome P450 3A (CYP3A), in both gastrointestinal tract and liver. Many drugs including saquinavir are substrates of both PGP and CYP3A. It was the aim of this study to test whether the extremely low bioavailability of saquinavir can be increased dose-dependently in vivo by cremophor EL, an 'inactive' pharmaceutic aid known… CONTINUE READING
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