Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol

  title={Dose-dependent hypocholesterolemic actions of dietary apple polyphenol in rats fed cholesterol},
  author={Kyoichi Osada and Takashi Suzuki and Yuki Kawakami and Mineo Senda and Atsushi Kasai and Manabu Sami and Yutaka Ohta and Tomomasa Kanda and Mitsuo Ikeda},
The dose-dependent hypocholesterolemic and antiatherogenic effects of dietary apple polyphenol (AP) from unripe apple, which contains approximately 85% catechin oligomers (procyanidins), were examined in male Sprague-Dawley rats (4 wk of age) given a purified diet containing 0.5% cholesterol. Dietary AP at 0.5 and 1.0% levels significantly decreased the liver cholesterol level compared with that in the control (AP-free dietfed) group. Dietary AP also significantly lowered the serum cholesterol… CONTINUE READING


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Effects of Dietary Procyanidins and Tea Polyphenols on Adipose Tissue Mass and Fatty Acid Metabolism in Rats on a High Fat Diet

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