Dose-dependent half-life of glycine

@article{Hahn2004DosedependentHO,
  title={Dose-dependent half-life of glycine},
  author={Robert G. Hahn},
  journal={Urological Research},
  year={2004},
  volume={21},
  pages={289-291}
}
  • R. Hahn
  • Published 2004
  • Medicine
  • Urological Research
SummaryThe serum concentration of glycine was measured at hourly intervals after administration of between 10 and 91 g glycine to 17 patients undergoing transurethral resection of the prostate and of between 15 and 22 g glycine to 18 volunteers by intravenous infusion. [] Key Result The apparent half-life of glycine varied 10-fold (range 26–245 min) and increased in direct proportion to the amount of glycine given. This result can be explained by assuming a marked intracellular accumulation of a surplus of…
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  • R. Hahn
  • Medicine
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  • 2013
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  • R. Hahn
  • Medicine
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  • 2006
TLDR
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TLDR
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TLDR
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Excessive Fluid Overload With Severe Hyponatremia, Cardiac Failure, and Cerebral Edema Complicating Hysteroscopic Myomectomy: A Case Report and Review of the Literature
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awareness of the risk of fluid overload and early recognition, by guiding the surgeon with constant feedback about fluid absorption, are important in preventing a fatal outcome.
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References

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TLDR
There was an increase in the excretion of all amino acids that could be detected in the urine and the absence of toxic symptoms is consistent with unchanged serum concentrations of ammonia and glutamate.
Serum amino acid patterns and toxicity symptoms following the absorption of irrigant containing glycine in transurethral prostatic surgery
  • R. Hahn
  • Medicine
    Acta anaesthesiologica Scandinavica
  • 1988
The relationships between the scrum concentrations of amino acids, the volume of irrigating fluid absorbed and symptoms of glycine toxicity were analysed in 18 patients who had undergone
Glycine solution as an irrigating agent during transurethral prostatic resection. Glycine concentrations in blood plasma.
TLDR
The authors conclude that the irrigating fluid should have a minimal concentration of glycine, near to the level of haemolysis onset, to minimize the plasma dilution effects, including hyponatraemia, and the appearance of metabolites when the irrigate fluid is absorbed.
Effects of isosmotic and hyperosmotic glycine solutions on the fluid balance in conscious sheep
TLDR
At the end of the follow‐up period, the isosmotic glycine solution had resulted in hyperhydration of the ICF and the hyperosmosis solution in dehydration of theICF, whereas with both fluids, the ECF resumed the same volume as before the experiments.
Amino acid concentrations in plasma and skeletal muscle after transurethral resection syndrome.
TLDR
The data suggest that skeletal muscle is a quantitatively important reservoir for glycine when this amino acid is supplied in potentially toxic amounts, but that the plasma glycine concentration returns to normal as the patient's clinical condition improves.
Haemodynamics and fluid balance after intravenous infusion of 1.5% glycine in sheep
TLDR
It is concluded that i.v. infusion of 1.5% glycine solution in sheep causes a transient circulatory strain and natriuresis, and a vasopressin‐mediated reduction of maximal water excretion contributes to persisting hypoosmolality.
Irrigating fluid absorption and blood loss during transurethral resection of the prostate studied with a regular interval monitoring (RIM) method.
TLDR
In 20 patients undergoing TUR, irrigating fluid absorption occurred throughout the procedure although the risk of having an absorption increased 30 min after surgery commenced, and the total intraoperative blood loss was not greater in patients with large absorption volumes.
Visual disturbances, serum glycine levels and transurethral resection of the prostate.
Transurethral resection of the prostate, serum glycine levels, and ocular evoked potentials.
TLDR
Elevated serum levels of glycine may contribute directly to visual aberrations resulting from glycine's role as an inhibitory transmitter in the retina resulting from sedative effects of diazepam.
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