Dose-dependent enhancements by interferon-gamma on functional responses of neutrophils from chronic granulomatous disease patients.

@article{hlin1997DosedependentEB,
  title={Dose-dependent enhancements by interferon-gamma on functional responses of neutrophils from chronic granulomatous disease patients.},
  author={Anders {\AA}hlin and G{\"o}ran Elinder and Jan Palmblad},
  journal={Blood},
  year={1997},
  volume={89 9},
  pages={3396-401}
}
Interferon-gamma (IFN-gamma) is recommended as prophylaxis against infections in patients with chronic granulomatous disease (CGD). However, since the optimal dose, the dosing interval, and the mechanisms of action are not well-defined, we studied the effects on CGD neutrophil (PMN) functions ex vivo of interferon-gamma (IFN-gamma). Evaluations were made on oxidative capacity, measured by superoxide anion production and chemiluminescence after stimulation with f-met-leu-phe (f-MLP) or phorbol… CONTINUE READING

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