Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring.

@article{Savage2002DosedependentEO,
  title={Dose-dependent effects of prenatal ethanol exposure on synaptic plasticity and learning in mature offspring.},
  author={Daniel D Savage and Matthew Becher and Alejandro J de la Torre and Robert James Sutherland},
  journal={Alcoholism, clinical and experimental research},
  year={2002},
  volume={26 11},
  pages={1752-8}
}
BACKGROUND We have observed profound deficits in hippocampal synaptic plasticity and one-trial learning in offspring whose mothers drank moderate quantities of ethanol during pregnancy. In the present study, we examined the question of whether lower maternal blood ethanol concentrations (BECs) could produce functional deficits in offspring. METHODS Rat dams consumed either a 2%, 3%, or 5% ethanol liquid diet throughout gestation. Three other groups of dams were pair-fed a 0% ethanol liquid… CONTINUE READING

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