Dose-dependent effects of phytoestrogens on bone

@article{Dang2005DosedependentEO,
  title={Dose-dependent effects of phytoestrogens on bone},
  author={Z. C. Dang and Clemens Lowik},
  journal={Trends in Endocrinology \& Metabolism},
  year={2005},
  volume={16},
  pages={207-213}
}
  • Z. Dang, C. Lowik
  • Published 1 July 2005
  • Biology, Medicine
  • Trends in Endocrinology & Metabolism
View on Elsevier
doi.org
119 Citations
Highly Influential Citations
5
Background Citations
38
Methods Citations
1
Results Citations
1

119 Citations

Bone Sparing Effect of a Novel Phytoestrogen Diarylheptanoid from Curcuma comosa Roxb. in Ovariectomized Rats
TLDR
The results suggest that DPHD has a bone sparing effect in ovariectomy-induced trabecular bone loss and prevents deterioration of bone microarchitecture by suppressing the rate of bone turnover.
Isoflavonoid-based bone-sparing treatments exert a low activity on reproductive organs and on hepatic metabolism of estradiol in ovariectomized rats.
Dose‐dependent effects of soy phyto‐oestrogen genistein on adipocytes: mechanisms of action
  • Z. Dang
  • Biology, Medicine
    Obesity reviews : an official journal of the International Association for the Study of Obesity
  • 2009
TLDR
This review focuses on the role of soy phyto‐oestrogen genistein in adipocytes and the underlying mechanisms of action, and shows that genisteIn dose‐dependently inhibits and stimulates adipogenesis in vitro.
on ‘ Diet and bone health ’ Phyto-oestrogens and bone health
TLDR
Phyto-oestrogens are a source for putative innovative dietary health intervention for post-menopausal women, however, more data are necessary, particularly in relation to their effect on the risk of fracture.
Protective effect of apigenin on ovariectomy-induced bone loss in rats.
NO-donating genistein prodrug alleviates bone loss in ovariectomised rats.
TLDR
The NO-releasing prodrug of genistein improves the bone loss in OVX rats without stimulatory effects on the uterus, which suggests that the product could potentially be used for the prevention and treatment of postmenopausal osteoporosis.
The effects of luteolin on osteoclast differentiation, function in vitro and ovariectomy-induced bone loss.
Protective Effect of Puerariae Radix on Ovariectomy-induced Bone Loss in Rats
TLDR
The results showed that PR increased mineral content and density of the trabecular bone at the neck of the left femur and biochemical data indicated that PR had a positive effect on bone turnover.
Equol promotes rat osteoblast proliferation and differentiation through activating estrogen receptor.
TLDR
It is demonstrated that equol could promote the proliferation and differentiation of rat osteoblasts through activating the ER-PKCα-related signaling pathway, suggesting thatEquol could promotes bone formation and be a potential alternative agent for the management of postmenopausal osteoporosis.
Comparative effects of 17β-estradiol and phytoestrogens in the regulation of endometrial functions in the rodent uterus
TLDR
Data from this study show that PPARy and VEGFR-2 represent additional targets by which sex steroid estrogen and plant-derived phytoestrogens may, at certain doses, differentially regulate endometrial functions.
...
...

References

SHOWING 1-10 OF 66 REFERENCES
Dietary Phytoestrogens and Bone Health
  • A. Cassidy
  • Medicine, Biology
    The journal of the British Menopause Society
  • 2003
TLDR
Data from a long-term study suggest soy phytoestrogens have a bone conserving effect in menopausal women but to accurately examine the relative importance of these compounds for bone health in postmenopausal women an assessment of consumption on fracture rates will be critical.
Dietary phytoestrogens and their effect on bone: evidence from in vitro and in vivo, human observational, and dietary intervention studies.
TLDR
The collective data suggest that diets rich in phytoestrogens have bone-sparing effects in the long term, although the magnitude of the effect and the exact mechanism(s) of action are presently elusive or speculative.
Dietary phyto-oestrogens and bone health
  • F. Branca
  • Biology
    Proceedings of the Nutrition Society
  • 2003
TLDR
The use of dietary phyto-oestrogens as a possible option for the prevention of osteoporosis has raised considerable interest, but the evidence in support of a bone-sparing effect in post-menopausal women is still not sufficiently convincing.
The effects of estrogen on osteoprotegerin, RANKL, and estrogen receptor expression in human osteoblasts.
Phytoestrogen genistein stimulates the production of osteoprotegerin by human trabecular osteoblasts
TLDR
The data suggest that the phytoestrogen genistein is capable of upregulating the production of OPG by human osteoblasts, and dietary sources of phy toestrogens may help to prevent bone resorption and bone loss by enhanced osteoblastic production ofOPG.
Effects of phytoestrogens and environmental estrogens on osteoblastic differentiation in MC3T3-E1 cells.
Difference in effective dosage of genistein on bone and uterus in ovariectomized mice.
TLDR
There is a marked difference between genistein dosages that protect against bone loss and those that induce uterine hypertrophy, suggesting that there are endocrine disrupters in isoflavones that are effective on bone and uterus.
Phytoestrogen-low diet for endocrine disruptor studies.
TLDR
A NIH-07-based open formula "phytoestrogen-low diet" (PLD) is proposed, which effectively reduces uterine weight as well as the uterine luminal epithelial labeling index in ovariectomized rats.
Isoflavones and skeletal health: are these molecules ready for clinical application?
TLDR
Evidence from animal models, in vitro experiments, and epidemiological reports suggest that the isoflavones have skeletal benefits in women with little or no ovarian estrogen production, and a clear need exists for prospective human trials, using the required conditions of randomized clinical trials and designs.
Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys.
TLDR
It is suggested that SPE may be poor substitutes for mammalian estrogens in protecting against bone loss resulting from estrogen deficiency in ovariectomized female monkeys.
...
...