Dose-dependent effects of phytoestrogens on bone

  title={Dose-dependent effects of phytoestrogens on bone},
  author={Z. C. Dang and C. Lowik},
  journal={Trends in Endocrinology & Metabolism},
  • Z. C. Dang, C. Lowik
  • Published 2005
  • Chemistry, Medicine
  • Trends in Endocrinology & Metabolism
  • Phytoestrogens have the potential to maintain bone health and delay or prevent osteoporosis. This review focuses on their dose-dependent effects on bone and their possible mechanisms of action. Phytoestrogens exert biphasic dose-dependent effects on osteoblasts and osteoprogenitor cells, stimulating osteogenesis at low concentrations and inhibiting osteogenesis at high concentrations. They inhibit osteoclast formation and activity. Recent data show that the balance between estrogen receptors… CONTINUE READING
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