Dose-dependent effects of oral dronedarone on the circadian variation of RR and QT intervals in healthy subjects: implications for antiarrhythmic actions.

@article{Wadhani2006DosedependentEO,
  title={Dose-dependent effects of oral dronedarone on the circadian variation of RR and QT intervals in healthy subjects: implications for antiarrhythmic actions.},
  author={Nitin N Wadhani and Jonnalagedda S.M. Sarma and B. S. Nara Singh and Daniele Radzik and Christine Gaud},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2006},
  volume={11 3},
  pages={
          184-90
        }
}
Dronedarone, a non-iodinated benzofuran derivative, was developed as a potentially less toxic alternative to amiodarone. This study describes Holter data of dronedarone in humans. Five groups of healthy subjects were given 1 of 5 oral doses of dronedarone in a twice-daily regimen or placebo. Holter recordings of circadian rhythmicity of RR and QT intervals were evaluated. Dronedarone prolonged RR and QT intervals as a function of dose, without effect on circadian patterns. The relative… CONTINUE READING
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