Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice.

@article{Peters2011DosedependentEO,
  title={Dose-dependent effects of leucine supplementation on preservation of muscle mass in cancer cachectic mice.},
  author={Scott J. Peters and Ardy van Helvoort and Diane Kegler and Josep Maria Argil{\'e}s and Yvette C. Luiking and Alessandro Laviano and Jeroen van Bergenhenegouwen and Nicolaas E P Deutz and Henk P Haagsman and Marchel Gorselink and Klaske van Norren},
  journal={Oncology reports},
  year={2011},
  volume={26 1},
  pages={247-54}
}
Cancer cachexia, which is characterized by muscle wasting, is associated with increased morbidity and mortality. Because muscle protein synthesis may be increased and protein breakdown reduced by leucine supplementation, we used the C26 tumor-bearing cachectic mouse model to assess the effects of dietary supplementation with leucine on muscle weight and the markers of muscle protein breakdown (mRNA of atrogin and murf). Male CD2F1 mice were subcutaneously inoculated with tumor cells (tumor… CONTINUE READING
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