Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart.

@article{Wolf2009DosedependentEO,
  title={Dose-dependent effects of intravenous allogeneic mesenchymal stem cells in the infarcted porcine heart.},
  author={David Wolf and Adrian Reinhard and Anja Seckinger and Hugo A. Katus and Helmut K{\"u}cherer and Alexander R Hansen},
  journal={Stem cells and development},
  year={2009},
  volume={18 2},
  pages={321-9}
}
Intravenous delivery of mesenchymal stem cells (MSCs) preserves myocardial function after infarction. This dose-escalating study was performed to examine pathologic remodeling and scar formation in a pig model of permanent coronary occlusion without restoration of reperfusion. MSCs labeled with fluorescent dye 48 h or saline (negative control, n = 8) were given intravenously 48 h post proximal left anterior descending artery occlusion. Animals received either autologous or allogeneic MSCs in… CONTINUE READING

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