Dose-dependent effects of endotoxin on human sleep.

@article{Mullington2000DosedependentEO,
  title={Dose-dependent effects of endotoxin on human sleep.},
  author={J. Mullington and C. Korth and D. Hermann and A. Orth and C. Galanos and F. Holsboer and T. Pollm{\"a}cher},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2000},
  volume={278 4},
  pages={
          R947-55
        }
}
The role of the central nervous system in the host response to infection and inflammation and modulation of these responses by the hypothalamic-pituitary-adrenal system are well established. In animals, activation of host defense mechanisms increases non-rapid eye movement (NREM) sleep amount and intensity, which, in turn, are thought to support host defense, or the body's ability to defend itself against challenges to its immune system. In humans, the evidence is conflicting. Therefore, we… Expand
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