Dose-dependent effects of corticosterone on nuclear glucocorticoid receptors and their binding to DNA in the brain and pituitary of the rat.

Abstract

The glucocorticoid receptor (GR) is a transcription factor which regulates glucocorticoid-mediated negative feed-back of the HPA axis. In this study, we have investigated the dose-dependent effects of corticosterone on nuclear GR and GR-DNA binding in the brain and pituitary of adult adrenalectomized male rats. Rats were injected with either saline (1 ml/kg… (More)
DOI: 10.1016/j.brainres.2009.02.001

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@article{Spiga2009DosedependentEO, title={Dose-dependent effects of corticosterone on nuclear glucocorticoid receptors and their binding to DNA in the brain and pituitary of the rat.}, author={Francesca Spiga and Stafford Lightman}, journal={Brain research}, year={2009}, volume={1293}, pages={101-7} }