Dose-dependent effects of chronic treatment with estradiol or progesterone on LH secretion in ovariectomized rats.

@article{Ratka1990DosedependentEO,
  title={Dose-dependent effects of chronic treatment with estradiol or progesterone on LH secretion in ovariectomized rats.},
  author={Anna Ratka and J. W. Simpkins},
  journal={Endocrine research},
  year={1990},
  volume={16 2},
  pages={
          165-84
        }
}
Ovariectomized (OVX) Sprague-Dawley rats bearing atrial cannulae were implanted subcutaneously with fused pellets containing estradiol (E2) or progesterone (P4). Variable doses of E2 (0.1, 0.5, 1 and 5%) or P4 (10, 50, 75, 100%) were achieved by varying the ratio of the hormone to cholesterol (CHOL) in the pellet. Control groups were treated with CHOL containing pellets. Blood samples were collected in the morning and afternoon the day before and 1, 2, 5, 8, 11 and 14 days after pellet… CONTINUE READING

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