Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice

@article{Peters2014DosedependentEO,
  title={Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice},
  author={Sebastian Thomas Peters and David A Slattery and Nicole Uschold-Schmidt and Stefan O Reber and Inga D. Neumann},
  journal={Psychoneuroendocrinology},
  year={2014},
  volume={42},
  pages={225-236}
}
Chronic psychosocial stress is a recognized risk factor for various affective and somatic disorders. In an established murine model of chronic psychosocial stress, exposure to chronic subordinate colony housing (CSC) results in an alteration of physiological, behavioral, neuroendocrine and immunological parameters, including a long-lasting increase in anxiety, adrenal hypertrophy and thymus atrophy. Based on the stress-protective and anxiolytic properties of oxytocin (OXT) after acute… CONTINUE READING
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