Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat.

@article{Nagy1983DosedependentEO,
  title={Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat.},
  author={J. I. Nagy and Leslie Lars Iversen and Michel Goedert and Debra Chapman and Stephen P. Hunt},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1983},
  volume={3 2},
  pages={399-406}
}
The numbers of myelinated and unmyelinated fibers were counted in dorsal roots of adult rats treated neonatally with capsaicin in doses ranging from 5 to 100 mg/kg. Substance P and somatostatin levels in the spinal cord, dorsal roots, and sensory ganglia also were determined in control and treated animals. Capsaicin administration lead to the loss of both small myelinated and unmyelinated fibers from dorsal roots. However, whereas a near total loss, up to 94%, of unmyelinated fibers was… CONTINUE READING

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