Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats.

@article{Pechlivanova2010DosedependentEO,
  title={Dose-dependent effects of caffeine on behavior and thermoregulation in a chronic unpredictable stress model of depression in rats.},
  author={Daniela Marinova Pechlivanova and Jane Tchekalarova and Roumen Nikolov and Krassimira S. Yakimova},
  journal={Behavioural brain research},
  year={2010},
  volume={209 2},
  pages={205-11}
}
The effects of the non-selective adenosine A(1)/A(2) receptor antagonist caffeine on behavior and thermoregulation in chronic unpredictable stress (CUS) model of depression was studied in Wistar rats. In the open field (OF) test, caffeine dose-dependently increased motor activity while decreased grooming and time spent in the corner. Five-week exposure to CUS procedure had the opposite effect in rats. Caffeine reversed CUS-induced effects on the above mentioned parameters. Caffeine (40 mg/kg… CONTINUE READING
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Dose - dependent effect of caffeine in a chronic mild stress of depression in ICR mice

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