Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine.

@article{Mizutani2007DosedependentDR,
  title={Dose-dependent differential regulation of cytokine secretion from macrophages by fractalkine.},
  author={Noriko Mizutani and Toshiharu Sakurai and Takahiro Shibata and Koji Uchida and Jun Fujita and Rei Kawashima and Yuki I. Kawamura and Noriko Toyama-Sorimachi and Toshio Imai and Taeko Dohi},
  journal={Journal of immunology},
  year={2007},
  volume={179 11},
  pages={7478-87}
}
Although expression of the fractalkine (CX3CL1, FKN) is enhanced in inflamed tissues, it is detected at steady state in various organs such as the intestine, and its receptor CX3CR1 is highly expressed in resident-type dendritic cells and macrophages. We hypothesized that FKN might regulate the inflammatory responses of these cells. Therefore, murine macrophages were pretreated with FKN and then stimulated with LPS. We found that macrophages pretreated with 0.03 nM FKN but not with 3 nM FKN… CONTINUE READING