Dose-dependent differential effects of thrombin in allergic bronchial asthma.

@article{Miyake2013DosedependentDE,
  title={Dose-dependent differential effects of thrombin in allergic bronchial asthma.},
  author={Yoshihiro Miyake and Corina N D'Alessandro-Gabazza and Takehiro Takagi and Masahiro Naito and Osamu Hataji and Hiroki Nakahara and Hisamichi Yuda and Hiroyoki Fujimoto and Hiroshi Kobayashi and Taro Yasuma and Mitsunori Toda and Tetsuro Kobayashi and Yuristella Yano and John Morser and Osamu Taguchi and Esteban C Gabazza},
  journal={Journal of thrombosis and haemostasis : JTH},
  year={2013},
  volume={11 10},
  pages={
          1903-15
        }
}
BACKGROUND Apart from its role in the coagulation system, thrombin plays an important role in the inflammatory response through its protease-activated receptors (PARs). However, the role of thrombin in the immune response is not clear. OBJECTIVE To evaluate whether thrombin has a modulatory role in allergic bronchial asthma. METHODS Bronchial asthma was induced in mice by intraperitoneal sensitization and inhalation challenge with ovalbumin. Thrombin or its inhibitors were administered by… CONTINUE READING
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