Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.

@article{Lu2007DosedependentCB,
  title={Dose-dependent cross-talk between the transforming growth factor-beta and interleukin-1 signaling pathways.},
  author={Tao Lu and Liping Tian and Yulong Han and Michael A. Vogelbaum and George R Stark},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 11},
  pages={4365-70}
}
Some tumor cell lines secrete high concentrations of TGFbeta or IL-1. Similarly high concentrations of each of these cytokines cross-activate the other pathway: TGFbeta activates NFkappaB, and IL-1beta activates Smads. The IL-1 signaling components IRAK, MyD88, TRAF6, and TAK1 are all required for cross-activation of NFkappaB by TGFbeta. Knockdown experiments revealed that both TGFbeta receptor subunits are required for IL-1beta to activate Smads, and the IL-1 receptor is required for TGFbeta… CONTINUE READING

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