Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans.

@article{Newcomer1998DosedependentCI,
  title={Dose-dependent cortisol-induced increases in plasma leptin concentration in healthy humans.},
  author={John W. Newcomer and Gregg Selke and Angela Kelly Melson and Jasmin Gross and George P. Vogler and Samuel Dagogo-Jack},
  journal={Archives of general psychiatry},
  year={1998},
  volume={55 11},
  pages={995-1000}
}
BACKGROUND Leptin is a hormone that regulates fat metabolism and appetite. The secretion of leptin is regulated by adiposity and, in the rodent, by factors such as insulin, beta-adrenergic agonists, and glucocorticoids (GCs). Increased secretion of the endogenous human GC, cortisol, occurs during stress and in disorders such as major depression. Pharmacological GCs can robustly increase plasma leptin concentrations in humans, leading us to hypothesize that cortisol may serve as a physiological… CONTINUE READING

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