Corpus ID: 32775583

Dose-dependent cholesterolemic activity of tocotrienols.

  title={Dose-dependent cholesterolemic activity of tocotrienols.},
  author={Hunteik Khor and Thengtheng Ng and Raajeswari Rajendran},
  journal={Malaysian journal of nutrition},
  volume={8 2},
Tocotrienols and tocopherols are isoforms of vitamin E. Vitamin E may exhibit antioxidant, prooxidant and non-antioxidant activities depending upon circumstances. In this study, the effect of tocotrienols and a-tocopherol on the activities of HMG CoA reductase and cholesterol 7 a-hydroxylase was investigated. Pure tocotrienols were isolated from palm fatty acid distillate and pure a-tocopherol was obtained commercially. Guinea pigs were treated with different dosages of tocotrienols and a… Expand
2 Citations
Tocotrienol and Its Role in Chronic Diseases.
It is revealed that tocotrienol shows promising effects in preventing or treating the health conditions previously mentioned in in vivo and in vitro models, and should motivate researchers to explore its potential use in human. Expand
Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence
The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders. Expand


Tocotrienols inhibit liver HMG CoA reductase activity in the guinea pig
The results show that tocotrienols isolated from PFAD inhibited liver HMG CoA reductase activity in the guinea pig and the inhibitory effect of tocotrianols on H MG CoA Reduxase appeared to be dose-dependent. Expand
Dietary α-Tocopherol Attenuates the Impact of γ-Tocotrienol on Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Chickens
It is reported that including alpha-tocopherol in tocol blends containing adequate gamma-tocotrienol to suppress 3-hydroxy-3-methylglutaryl coenzyme A reductase activity results in an attenuation of the tocotrienol action. Expand
Effects of administration of alpha-tocopherol and tocotrienols on serum lipids and liver HMG CoA reductase activity.
  • H. Khor, T. Ng
  • Biology, Medicine
  • International journal of food sciences and nutrition
  • 2000
The results indicate that the alpha-T is hypercholesterolemic in the hamster and its effect on liver HMGCR is dose-dependent, indicating that the COTG with its fatty acids are responsible for the hypocholesterolesmic effect exhibited by corn oil. Expand
Differential serum responses of tocopherols and tocotrienols during vitamin supplementation in hypercholesterolaemic individuals without change in coronary risk factors
Abstract The effects of tocotrienol-rich vitamin E from palm oil on serum vitamin E concentrations, serum lipids, plasma prostaglandins and platelet function (assessed by bleeding time andExpand
Synergistic effect of tocotrienol-rich fraction (TRF(25)) of rice bran and lovastatin on lipid parameters in hypercholesterolemic humans.
The increased effectiveness of low doses of tocotrienols (TRF(25)) as hypocholesterolemic agents might be due to a minimum conversion to alpha-tocopherol, which is consistent with the synergistic effect of these two agents. Expand
Vitamin E: non-antioxidant roles.
Vitamin E was originally considered a dietary factor of animal nutrition especially important for normal reproduction. The significance of vitamin E has been subsequently proven as a radical chainExpand
Hypocholesterolemic activity of synthetic and natural tocotrienols.
The synthetic (racemic) and natural tocotrienols exhibit nearly identical cholesterol biosynthesis inhibition and HMG-CoA reductase suppression properties as demonstrated in vitro and in vivo. Expand
A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations.
The tocotrienol supplements used had no marked favorable effects on the serum lipoprotein profile or on platelet function in men with slightly elevated lipid concentrations. Expand
The structure of an inhibitor of cholesterol biosynthesis isolated from barley.
The addition of purified inhibitor I to chick diets significantly decreased hepatic cholesterogenesis and serum total and low density lipoprotein cholesterol and concomitantly increased lipogenic activity. Expand
Low-Dose α-Tocopherol Improves and High-Dose α- Tocopherol Worsens Endothelial Vasodilator Function in Cholesterol-Fed Rabbits
The data indicate that modest dietary treatment with AT preserves endothelial vasodilator function in cholesterol-fed rabbits while a higher dose of AT is associated with endothelial dysfunction and enhanced intimal proliferation despite continued LDL resistance to ex vivo copper-mediated oxidation. Expand