Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury.

@article{Chan2005DosedependentBA,
  title={Dose-dependent beneficial and detrimental effects of ROCK inhibitor Y27632 on axonal sprouting and functional recovery after rat spinal cord injury.},
  author={Carmen C M Chan and Kourosh Khodarahmi and Jie Liu and Darren P. Sutherland and Loren W Oschipok and John D. Steeves and Wolfram Tetzlaff},
  journal={Experimental neurology},
  year={2005},
  volume={196 2},
  pages={352-64}
}
Axonal regeneration within the injured central nervous system (CNS) is hampered by multiple inhibitory molecules in the glial scar and the surrounding disrupted myelin. Many of these inhibitors stimulate, either directly or indirectly, the Rho intracellular signaling pathway, providing a strong rationale to target it following spinal cord injuries. In this study, we infused either control (PBS) or a ROCK inhibitor, Y27632 (2 mM or 20 mM, 12 microl/day for 14 days) into the intrathecal space of… CONTINUE READING