Dose-dependent Toxicity of Humanized Renilla reniformis GFP (hrGFP) Limits Its Utility as a Reporter Gene in Mouse Muscle

@inproceedings{Wallace2013DosedependentTO,
  title={Dose-dependent Toxicity of Humanized Renilla reniformis GFP (hrGFP) Limits Its Utility as a Reporter Gene in Mouse Muscle},
  author={Lindsay M. Wallace and Andrew Moreo and Kelly Reed Clark and Scott Q. Harper},
  booktitle={Molecular therapy. Nucleic acids},
  year={2013}
}
Gene therapy has historically focused on delivering protein-coding genes to target cells or tissues using a variety of vectors. In recent years, the field has expanded to include gene-silencing strategies involving delivery of noncoding inhibitory RNAs, such as short hairpin RNAs or microRNAs (miRNAs). Often called RNA interference (RNAi) triggers, these… CONTINUE READING