Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin

@article{Tashiro2009DoseDO,
  title={Dose dependency of brain histamine H1 receptor occupancy following oral administration of cetirizine hydrochloride measured using PET with [11C]doxepin},
  author={M. Tashiro and Motohisa Kato and M. Miyake and S. Watanuki and Y. Funaki and Y. Ishikawa and R. Iwata and K. Yanai},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2009},
  volume={24}
}
The strength of sedation due to antihistamines can be evaluated using positron emission tomography (PET). The purpose of the present study is to measure histamine H1 receptor (H1R) occupancy following oral administration of cetirizine (10 and 20 mg) in order to examine dose dependency. 
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