Dose dependency of aflatoxin B1 binding on human high molecular weight DNA in the activation of proto-oncogene.

  title={Dose dependency of aflatoxin B1 binding on human high molecular weight DNA in the activation of proto-oncogene.},
  author={S S Yang and Janet Taub and Rama V. Modali and Wellington Dorigheto Andrade Vieira and P Yasei and G. C. Yang},
  journal={Environmental Health Perspectives},
  pages={231 - 238}
The binding of aflatoxin B1, AFB1, a potent hepatocarcinogen, to various high molecular weight (HMW) DNAs from human normal liver and two liver cancer cell lines, Alexander primary liver carcinoma (PLC) and Mahlavu hepatocellular carcinoma (hHC) and from NIH/3T3 cell have been investigated. The kinetics of AFB1 binding to these DNAs showed similar initial rates but the extents of binding to the PLC and hHC DNAs seemed to be slightly higher. Preferential AFB1 bindings were identified in both PLC… 

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