Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine.

@article{Peto1991DoseAT,
  title={Dose and time relationships for tumor induction in the liver and esophagus of 4080 inbred rats by chronic ingestion of N-nitrosodiethylamine or N-nitrosodimethylamine.},
  author={Roland Peto and Robert W. Gray and Paul G. Brantom and P. A. Grasso},
  journal={Cancer research},
  year={1991},
  volume={51 23 Pt 2},
  pages={6452-69}
}
A Weibull analysis is presented of the dose and time relationships for the effects on 4080 inbred rats of chronic ingestion in the drinking water of 16 different doses of N-nitrosodimethylamine (NDMA) or N-nitrosodiethylamine (NDEA). The sites chiefly affected were the liver (by both agents) and the esophagus (by NDEA only). Since the experiment continued on into extreme old age, effects became measurable at doses of only 0.01 to 0.02 mg/kg/day, which is an order of magnitude lower than… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 21 references

Quantitative aspects in chemical carcinogenesis

H. Druckrey
UICC Monograph Series, • 1967
View 7 Excerpts
Highly Influenced

The assessment of low-dose carcinogenicity.

Biometrics • 1982
View 6 Excerpts
Highly Influenced

The causes of cancer: quantitative estimates of avoidable risks of cancer

Doll
in the United States today. J. Nati. Cancer Inst., • 1981
View 5 Excerpts
Highly Influenced

Detection of risk of cancer to man.

Proceedings of the Royal Society of London. Series B, Biological sciences • 1979
View 5 Excerpts
Highly Influenced

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