Dose and time effects of nicotine treatment on the capillary blood flow and viability of random pattern skin flaps in the rat.

@article{Forrest1987DoseAT,
  title={Dose and time effects of nicotine treatment on the capillary blood flow and viability of random pattern skin flaps in the rat.},
  author={Christopher R. Forrest and C. Y. Amy Pang and W. Keith Lindsay},
  journal={British journal of plastic surgery},
  year={1987},
  volume={40 3},
  pages={295-9}
}
The deleterious effects of nicotine treatment on skin haemodynamics and survival of 4 X 10 cm acute random pattern skin flaps constructed on the dorsum of the rat were studied. Rats were injected subcutaneously with 0.2 ml of saline containing varying doses (0, 1, 2, 4 or 8 mg kg-1; bid) of nicotine for 5 weeks, starting 4 weeks before flap surgery. It was observed that nicotine treatment at the dose of 2 mg kg-1 (bid), or higher, significantly (p less than 0.05) decreased the length and area… CONTINUE READING

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