Dose- and time-dependent relations between infective Anopheles inoculation and outcomes of Plasmodium falciparum parasitemia among children in western Kenya.

@article{Mcelroy1997DoseAT,
  title={Dose- and time-dependent relations between infective Anopheles inoculation and outcomes of Plasmodium falciparum parasitemia among children in western Kenya.},
  author={Peter D. Mcelroy and John C. Beier and Charles N. Oster and F K Onyango and Aggrey J. Oloo and X Lin and C. Beadle and Stephen L. Hoffman},
  journal={American journal of epidemiology},
  year={1997},
  volume={145 10},
  pages={
          945-56
        }
}
Blood-stage level Plasmodium falciparum infection (parasitemia density) is generally elevated prior to, or at the time of, clinical presentation of severe pediatric malaria episodes. Intensity of exposure to infective Anopheles mosquito bites is a suspected determinant of higher density parasitemia. Analyses of entomologic and parasitologic data collected in 1986-1987 were conducted to investigate whether the dose of infective bites predicted the incidence or degree of P. falciparum parasitemia… 
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References

SHOWING 1-10 OF 48 REFERENCES
Predicting outcome in malaria: correlation between rate of exposure to infected mosquitoes and level of Plasmodium falciparum parasitemia.
The level of Plasmodium falciparum parasitemia at clinical presentation has repeatedly been shown to correlate with severity of disease. Using data collected in western Kenya over 21 months, we…
Impact of transmission intensity and age on Plasmodium falciparum density and associated fever: implications for malaria vaccine trial design.
TLDR
Malaria was studied in 6-month- to 6-year-old Kenyans during high (HI) and low intensity transmission seasons and there was a striking association between age and parasitemia > or = 5000/microL.
Plasmodium falciparum incidence relative to entomologic inoculation rates at a site proposed for testing malaria vaccines in western Kenya.
Relationships between Plasmodium falciparum incidence and entomologic inoculation rates (EIRs) were determined for a 21-month period in Saradidi, western Kenya, in preparation for malaria vaccine…
Age-dependent acquired protection against Plasmodium falciparum in people having two years exposure to hyperendemic malaria.
An epidemiologic study of susceptibility to frequent and high-grade parasitemia by Plasmodium falciparum revealed that age-dependent acquired protection developed within a two-year period of exposure…
Relationships between Plasmodium falciparum transmission by vector populations and the incidence of severe disease at nine sites on the Kenyan coast.
TLDR
At these sites on the coast of Kenya, a high incidence of severe disease occurs under conditions of very low levels of transmission by vector populations, with respect to conventional approaches for vector control in Africa, decreases in transmission, even to levels barely detectable by standard approaches, may not yield corresponding long-term reductions in the incidence ofsevere disease.
Infecting dose and severity of falciparum malaria.
Inoculum size, incubation period and severity of malaria. Analysis of data from malaria therapy records.
TLDR
In the largest data set, longer pre-patent periods were associated with tertian fever, spontaneous recovery and less use of modifying treatment, while an inoculum size-severity relationship cannot be ruled out, and a strong relationship is very unlikely.
Criteria for diagnosing clinical malaria among a semi-immune population exposed to intense and perennial transmission.
Parasite virulence and disease patterns in Plasmodium falciparum malaria.
TLDR
Observed age-structured patterns of disease are used to define a population structure of P. falciparum, where the latter contains several independently transmitted antigenic types or "strains" that each induce some degree of strain-specific antidisease immunity upon infection.
Identification of malaria species by ELISA in sporozoite and oocyst infected Anopheles from western Kenya.
Enzyme-linked immunosorbent assays (ELISAs) for the circumsporozoite (CS) antigens of Plasmodium falciparum, P. malariae, and P. ovale were used to identify species of sporozoite and oocyst…
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