Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats.

@article{Zhang2007DoseAT,
  title={Dose- and time-dependent expression of anxiety-like behavior in the elevated plus-maze during withdrawal from acute and repeated intermittent ethanol intoxication in rats.},
  author={Zhongqi Zhang and Andrew C. Morse and George F. Koob and Gery Schulteis},
  journal={Alcoholism, clinical and experimental research},
  year={2007},
  volume={31 11},
  pages={1811-9}
}
BACKGROUND Withdrawal from acute bolus intraperitoneal (IP) injection of high doses of ethanol elicits anxiety-like behavior (e.g. Doremus et al., 2003; Gauvin et al., 1989, 1992) and conditioned place aversion (Morse et al., 2000). More recently we demonstrated that withdrawal from a single moderate dose of ethanol (2.0 g/kg) is accompanied by elevations in brain reward thresholds, and that repeated intermittent treatment with this dose results in a significant potentiation of reward deficit… CONTINUE READING

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