Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.

@article{Kuzmin2000DoseAT,
  title={Dose- and time-dependent bimodal effects of kappa-opioid agonists on locomotor activity in mice.},
  author={A Kuzmin and Johan Sandin and Lars Terenius and Sven Ove {\"O}gren Ogren},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 3},
  pages={1031-42}
}
The kappa-opioid agonists U50488H, bremazocine, and BRL52537, and the mu-opioid agonist morphine were compared in their ability to modify spontaneous motor activity in male NMRI mice. Higher, analgesic doses of the kappa-agonists reduced rearing, motility, and locomotion in nonhabituated mice. These effects, as well as the analgesic action of U50488H, were blocked by the selective kappa-opioid antagonists nor-binaltorphimine and DIPPA. In contrast, lower, subanalgesic doses (1.25 and 2.5 mg/kg… CONTINUE READING

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