Dose and route of administration alter the relative elimination of ethanol by long-sleep and short-sleep mice.

@article{Smolen1986DoseAR,
  title={Dose and route of administration alter the relative elimination of ethanol by long-sleep and short-sleep mice.},
  author={Andrew Smolen and Michael J. Marks and Toni Ness Smolen and Allan C. Collins},
  journal={Alcoholism, clinical and experimental research},
  year={1986},
  volume={10 2},
  pages={
          198-204
        }
}
The elimination of ethanol following the intravenous and intraperitoneal administration of five ethanol doses was measured in two mouse lines, the long-sleep (LS) and short-sleep (SS), that differ markedly in central nervous system sensitivity to ethanol. Both dose and route of administration affected the relative ethanol elimination in these two mouse lines. When the ethanol was given i.v., a steady increase in elimination rate was seen in the SS mice as the dose was increased. In the LS mice… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-8 of 8 citations