Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B.

@article{Budman1998DoseAD,
  title={Dose and dose intensity as determinants of outcome in the adjuvant treatment of breast cancer. The Cancer and Leukemia Group B.},
  author={Daniel R. Budman and Donald A. Berry and Constance T. Cirrincione and I. H. C. Henderson and William C. Wood and Raymond B. Weiss and Carolyn R Ferree and Hyman Bernard Muss and Mark L. Green and Larry Norton and Emil Frei},
  journal={Journal of the National Cancer Institute},
  year={1998},
  volume={90 16},
  pages={1205-11}
}
BACKGROUND Both total dose and dose intensity of adjuvant chemotherapy are postulated to be important variables in the outcome for patients with operable breast cancer. The Cancer and Leukemia Group B study 8541 examined the effects of adjuvant treatment using conventional-range dose and dose intensity in female patients with stage II (axillary lymph node-positive) breast cancer. METHODS Within 6 weeks of surgery (radical mastectomy, modified radical mastectomy, or lumpectomy), 1550 patients… CONTINUE READING
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