Dose-Response Curves for Liver DNA Fragmentation Induced in Rats by Sixteen 7 V-Nitroso Compounds as Measured by Viscometric and Alkaline Elution Analyses 1

A new viscometric technique, capable of detecting DNA strand breaks and alkali-labile sites by monitoring time-dependent changes of DNAreduced viscosity, has been used to analyze dose-response curves for the induction of DNA damage in liver of rats treated with single p.o. doses of sixteen A-nit roso compounds. Statistically significant changes of DNA… (More)