Dose-Related Differences in the Regional Pattern of Cannabinoid Receptor Adaptation and in Vivo Tolerance Development to Δ 9-Tetrahydrocannabinol

@inproceedings{McKinney2008DoseRelatedDI,
  title={Dose-Related Differences in the Regional Pattern of Cannabinoid Receptor Adaptation and in Vivo Tolerance Development to Δ 9-Tetrahydrocannabinol},
  author={Diana L. McKinney and Michael P. Cassidy and Lauren M. Collier and Billy R. Martin and Jenny L Wiley and D. E. Selley and L. J. Sim-Selley},
  year={2008}
}
Chronic treatment with -tetrahydrocannabinol (THC) produces tolerance to cannabinoid-mediated behaviors and region-specific adaptation of brain cannabinoid receptors. However, the relationship between receptor adaptation and tolerance is not well understood, and the dose-response relationship of THC-induced cannabinoid receptor adaptation is unknown. This study assessed cannabinoid receptor function in the brain and cannabinoid-mediated behaviors after chronic treatment with different dosing… CONTINUE READING